Hello, `python-shell-send-region' fails with the following error when the region starts in the middle of the first line. Wrong type argument: wholenump, -1 This is caused by the code to insert the coding cookie in `python-shell-buffer-substring'. I think that the current code assumes that the region begins at line beginning position. However, there are some use-cases where the region starts in the middle of the line as discussed in #60142. So I think the special treatment in case of point-min should be extended to case of first line. Attached is a patch to implement this. -- In GNU Emacs 30.0.50 (build 6, x86_64-pc-linux-gnu, X toolkit, cairo version 1.16.0, Xaw scroll bars) of 2023-01-01 built on ubuntu Repository revision: 9596e683834a36060497903b47b870b338d88095 Repository branch: master System Description: Ubuntu 22.04.1 LTS Configured features: ACL CAIRO FREETYPE GIF GLIB GMP GNUTLS GSETTINGS HARFBUZZ JPEG LIBSELINUX LIBXML2 MODULES NOTIFY INOTIFY PDUMPER PNG SECCOMP SOUND SQLITE3 THREADS TIFF TOOLKIT_SCROLL_BARS TREE_SITTER X11 XDBE XIM XPM LUCID ZLIB Important settings: value of $LANG: en_US.UTF-8 locale-coding-system: utf-8-unix Major mode: Lisp Interaction Minor modes in effect: tooltip-mode: t global-eldoc-mode: t eldoc-mode: t show-paren-mode: t electric-indent-mode: t mouse-wheel-mode: t tool-bar-mode: t menu-bar-mode: t file-name-shadow-mode: t global-font-lock-mode: t font-lock-mode: t blink-cursor-mode: t line-number-mode: t indent-tabs-mode: t transient-mark-mode: t auto-composition-mode: t auto-encryption-mode: t auto-compression-mode: t Load-path shadows: None found. Features: (shadow sort mail-extr emacsbug message mailcap yank-media puny dired dired-loaddefs rfc822 mml mml-sec password-cache epa derived epg rfc6068 epg-config gnus-util text-property-search time-date subr-x mm-decode mm-bodies mm-encode mail-parse rfc2231 mailabbrev gmm-utils mailheader cl-loaddefs cl-lib sendmail rfc2047 rfc2045 ietf-drums mm-util mail-prsvr mail-utils term/screen term/xterm xterm byte-opt gv bytecomp byte-compile rmc iso-transl tooltip cconv eldoc paren electric uniquify ediff-hook vc-hooks lisp-float-type elisp-mode mwheel term/x-win x-win term/common-win x-dnd tool-bar dnd fontset image regexp-opt fringe tabulated-list replace newcomment text-mode lisp-mode prog-mode register page tab-bar menu-bar rfn-eshadow isearch easymenu timer select scroll-bar mouse jit-lock font-lock syntax font-core term/tty-colors frame minibuffer nadvice seq simple cl-generic indonesian philippine cham georgian utf-8-lang misc-lang vietnamese tibetan thai tai-viet lao korean japanese eucjp-ms cp51932 hebrew greek romanian slovak czech european ethiopic indian cyrillic chinese composite emoji-zwj charscript charprop case-table epa-hook jka-cmpr-hook help abbrev obarray oclosure cl-preloaded button loaddefs theme-loaddefs faces cus-face macroexp files window text-properties overlay sha1 md5 base64 format env code-pages mule custom widget keymap hashtable-print-readable backquote threads inotify dynamic-setting system-font-setting font-render-setting cairo x-toolkit x multi-tty make-network-process emacs) Memory information: ((conses 16 45803 5938) (symbols 48 5813 0) (strings 32 14944 1951) (string-bytes 1 421917) (vectors 16 8284) (vector-slots 8 104561 8256) (floats 8 24 281) (intervals 56 200 0) (buffers 984 10))