From mboxrd@z Thu Jan 1 00:00:00 1970 Path: main.gmane.org!not-for-mail From: "The Investment Journal" Newsgroups: gmane.emacs.bugs,gmane.spam.detected Subject: The Investment Journal: Biotech Holdings Ltd. 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Wed, 24 Apr 2002 11:37:18 +0800 Original-To: Errors-To: bug-gnu-emacs-admin@gnu.org X-BeenThere: bug-gnu-emacs@gnu.org X-Mailman-Version: 2.0.9 Precedence: bulk List-Help: List-Post: List-Subscribe: , List-Id: Bug reports for GNU Emacs, the Swiss army knife of text editors List-Unsubscribe: , List-Archive: Xref: main.gmane.org gmane.emacs.bugs:934 gmane.spam.detected:15504 X-Report-Unspam: http://unspam.gmane.org/gmane.emacs.bugs:934 The Investment Journal</ti= tle><o:SmartTagType namespaceuri=3Durn:schemas-microsoft-com:office:smartt= ags name=3D"date"/><o:SmartTagType namespaceuri=3Durn:schemas-microsoft-co= m:office:smarttags name=3D"place"/><o:SmartTagType namespaceuri=3Durn:sche= mas-microsoft-com:office:smarttags name=3D"country-region"/><o:SmartTagTyp= e namespaceuri=3Durn:schemas-microsoft-com:office:smarttags name=3D"City"/= ><style><!--@font-face{font-family:"Arial Unicode MS";panose-1:0 0 0 0 0 0= 0 0 0 0;mso-font-charset:0;mso-generic-font-family:roman;mso-font-format:= other;mso-font-pitch:variable;mso-font-signature:3 0 0 0 1 0;}@font-face{f= ont-family:Algerian;panose-1:4 2 7 5 4 10 2 6 7 2;mso-font-charset:0;mso-g= eneric-font-family:decorative;mso-font-pitch:variable;mso-font-signature:3= 0 0 0 1 0;}@font-face{font-family:"Calisto MT";panose-1:2 4 6 3 5 5 5 3 3= 4;mso-font-charset:0;mso-generic-font-family:roman;mso-font-pitch:variabl= e;mso-font-signature:3 0 0 0 1 0;}@font-face{font-family:"Franklin Gothic = Demi";panose-1:2 11 7 3 2 1 2 2 2 4;mso-font-charset:0;mso-generic-font-fa= mily:swiss;mso-font-pitch:variable;mso-font-signature:647 0 0 0 159 0;}p.M= soNormal,li.MsoNormal,div.MsoNormal{mso-style-parent:"";margin:0in;margin-= bottom:.0001pt;mso-pagination:widow-orphan;font-size:12.0pt;font-family:"T= imes New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-languag= e:EN-CA;}h1{mso-style-next:Normal;margin:0in;margin-bottom:.0001pt;text-al= ign:justify;mso-pagination:widow-orphan;page-break-after:avoid;mso-outline= -level:1;font-size:12.0pt;font-family:"Times New Roman";mso-font-kerning:0= pt;mso-ansi-language:EN-CA;}h2{mso-style-next:Normal;margin:0in;margin-bot= tom:.0001pt;mso-pagination:widow-orphan;page-break-after:avoid;mso-outline= -level:2;font-size:12.0pt;font-family:"Times New Roman";mso-ansi-language:= EN-CA;}h3{mso-style-next:Normal;margin:0in;margin-bottom:.0001pt;text-alig= n:center;mso-pagination:widow-orphan;page-break-after:avoid;mso-outline-le= vel:3;font-size:36.0pt;mso-bidi-font-size:12.0pt;font-family:Algerian;colo= r:green;mso-ansi-language:EN-CA;}h5{mso-style-next:Normal;margin:0in;margi= n-bottom:.0001pt;text-align:center;mso-pagination:widow-orphan;page-break-= after:avoid;mso-outline-level:5;font-size:14.0pt;mso-bidi-font-size:12.0pt= ;font-family:Arial;mso-fareast-font-family:"Arial Unicode MS";mso-ansi-lan= guage:EN-GB;mso-bidi-font-weight:normal;}p.MsoHeader,li.MsoHeader,div.MsoH= eader{margin:0in;margin-bottom:.0001pt;mso-pagination:widow-orphan;tab-sto= ps:center 3.0in right 6.0in;font-size:12.0pt;font-family:"Times New Roman"= ;mso-fareast-font-family:"Times New Roman";}p.MsoBodyText,li.MsoBodyText,d= iv.MsoBodyText{margin:0in;margin-bottom:.0001pt;text-align:center;mso-pagi= nation:widow-orphan;border:none;mso-border-alt:solid windowtext .5pt;paddi= ng:0in;mso-padding-alt:1.0pt 4.0pt 1.0pt 4.0pt;font-size:36.0pt;mso-bidi-f= ont-size:12.0pt;font-family:Algerian;mso-fareast-font-family:"Times New Ro= man";mso-bidi-font-family:"Times New Roman";color:green;mso-ansi-language:= EN-CA;font-weight:bold;}p.MsoBodyText2,li.MsoBodyText2,div.MsoBodyText2{ma= rgin:0in;margin-bottom:.0001pt;text-align:center;mso-pagination:widow-orph= an;font-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial;mso-fareast= -font-family:"Times New Roman";mso-ansi-language:EN-CA;}a:link,span.MsoHyp= erlink{color:blue;text-decoration:underline;text-underline:single;}a:visit= ed,span.MsoHyperlinkFollowed{color:purple;text-decoration:underline;text-u= nderline:single;}span.SpellE{mso-style-name:"";mso-spl-e:yes;}span.GramE{m= so-style-name:"";mso-gram-e:yes;}@page Section1{size:8.5in 11.0in;margin:.= 25in .25in .25in .5in;mso-header-margin:.5in;mso-footer-margin:.5in;border= :solid windowtext 1.0pt;mso-border-alt:solid windowtext .5pt;padding:24.0p= t 24.0pt 24.0pt 24.0pt;mso-paper-source:0;}div.Section1{page:Section1;}-->= </style></head><body lang=3DEN-US link=3Dblue vlink=3Dpurple style=3Dtab-i= nterval:.5in><div class=3DSection1><div align=3Dcenter><table class=3DMsoN= ormalTable border=3D0 cellspacing=3D0 cellpadding=3D0 width=3D591 style=3D= 'width:443.45pt;margin-left:.45in;background:#E5D68D;border-collapse: collapse;mso-padding-alt:0in 5.4pt 0in 5.4pt;background-position-x:0%; background-position-y: 50%;background-attachment:scroll'><tr style=3Dmso-yfti-irow:0;mso-yfti-las= trow:yes;height:77.25pt><td width=3D591 nowrap valign=3Dtop style=3D'width= :443.45pt;padding:0in 5.4pt 0in 5.4pt; height:77.25pt'><h3><span lang=3DEN-CA>The Investment</span></h3><p class=3D= MsoNormal align=3Dcenter style=3Dtext-align:center><span lang=3DEN-CA styl= e=3D'font-size:10.0pt;mso-bidi-font-size:12.0pt;font-family:"Franklin Goth= ic Demi"; color:black'>Issue 23<span style=3Dmso-spacerun:yes>=FFFFFFA0=FFFFFFA0=FFF= FFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFF= FA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA= 0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0 </span></span><b><span lang=3DEN-CA = style=3D'font-size:36.0pt;mso-bidi-font-size: 12.0pt;font-family:Algerian;color:green'>Journal<span style=3Dmso-spacerun= :yes>=FFFFFFA0=FFFFFFA0=FFFFFFA0 </span></span></b><span lang=3DEN-CA styl= e=3D'font-size:10.0pt;mso-bidi-font-size:12.0pt;font-family:"Franklin Goth= ic Demi"; color:black'>April 2002</span><b><span lang=3DEN-CA style=3D'font-size:36.= 0pt; mso-bidi-font-size:12.0pt;font-family:Algerian;color:#999999'><o:p></o:p><= /span></b></p></td></tr></table></div><p class=3DMsoNormal align=3Dcenter = style=3Dtext-align:center><span lang=3DEN-CA style=3Dcolor:white><o:p>&nbs= p;</o:p></span></p><p class=3DMsoHeader align=3Dcenter style=3D'text-align= :center;tab-stops:.5in center 3.0in right 6.0in'><span lang=3DEN-CA style=3D= 'font-size:22.0pt;mso-bidi-font-size:12.0pt;font-family:Arial; color:white;mso-ansi-language:EN-CA'><span style=3Dmso-spacerun:yes>=FFFFF= FA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0 </span></span><span lang=3DEN-CA s= tyle=3D'font-size:22.0pt;mso-bidi-font-size:12.0pt; font-family:Arial;color:green;mso-ansi-language:EN-CA'>BIOTECH HOLDINGS LT= D.</span><span lang=3DEN-CA style=3D'font-size:22.0pt;mso-bidi-font-size:1= 2.0pt;font-family:Arial; color:white;mso-ansi-language:EN-CA'><o:p></o:p></span></p><p class=3DMsoH= eader style=3D'tab-stops:.5in center 3.0in right 6.0in'><span lang=3DEN-CA= style=3Dmso-ansi-language:EN-CA><o:p> </o:p></span></p><table class=3D= MsoNormalTable border=3D0 cellspacing=3D0 cellpadding=3D0 style=3D'border-= collapse:collapse;mso-padding-alt:0in 5.4pt 0in 5.4pt'><tr style=3Dmso-yft= i-irow:0;mso-yfti-lastrow:yes;height:549.0pt><td width=3D431 valign=3Dtop = style=3D'width:323.6pt;padding:0in 5.4pt 0in 5.4pt; height:549.0pt'><table class=3DMsoNormalTable border=3D0 cellspacing=3D0 c= ellpadding=3D0 style=3D'background:#E5D68D;border-collapse:collapse;mso-pa= dding-alt:0in 5.4pt 0in 5.4pt'><tr style=3Dmso-yfti-irow:0;mso-yfti-lastro= w:yes><td width=3D405 valign=3Dtop style=3D'width:303.4pt;padding:0in 5.4p= t 0in 5.4pt'><h1 align=3Dcenter style=3Dtext-align:center><span lang=3DEN-= CA style=3D'font-family:"Calisto MT";color:green'>BIOTECH HOLDINGS PROFILE= <o:p></o:p></span></h1><h1 align=3Dcenter style=3Dtext-align:center><span= lang=3DEN-CA style=3D'font-family:"Calisto MT";color:green'><span style=3D= mso-spacerun:yes>=FFFFFFA0</span>BREAKTHROUGH DIABETES DRUG</span><span la= ng=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-fon= t-family: Arial;color:green'><o:p></o:p></span></h1></td></tr></table><h1 align=3Dce= nter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size: 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial;color:green'><o= :p> </o:p></span></h1><p class=3DMsoNormal style=3Dtext-align:justify= ><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font= -family:Arial>The Company: Biotech is a pharmaceutical company based in </= span><st1:place><st1:City><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-= bidi-font-size:10.0pt;font-family: Arial'>Vancouver</span></st1:City><span lang=3DEN-CA style=3D'font-size:9.= 0pt; mso-bidi-font-size:10.0pt;font-family:Arial'>, </span><st1:country-region>= <span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font-size:10.0pt;font= -family: Arial'>Canada</span></st1:country-region></st1:place><span lang=3DEN-CA st= yle=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>.<span s= tyle=3Dmso-spacerun:yes>=FFFFFFA0 </span>Biotech <b>controls and is bringi= ng to market a breakthrough diabetes drug</b>.<span style=3Dmso-spacerun:y= es>=FFFFFFA0 </span>The drug, called DIAB II, is classed as an insulin-sen= sitizing drug. Drugs of this type improve the body=FFFFFF92s ability<o:p><= /o:p></span></p><p class=3DMsoNormal style=3Dtext-align:justify><span clas= s=3DGramE><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10= 0pt;font-family:Arial>to</span></span><span lang=3DEN-CA style=3Dfont-siz= e:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> make use of insulin, = the hormone that controls blood sugar levels.<span style=3Dmso-spacerun:ye= s>=FFFFFFA0 </span>Currently available insulin-sensitizers such as <span c= lass=3DSpellE>Avandia</span> and <span class=3DSpellE>Actos</span> have hu= ge sales <span class=3DGramE>volumes<span style=3Dmso-spacerun:yes>=FFFFFF= A0 </span>--</span> <b>over $700 million annually in the case of <span cla= ss=3DSpellE>Avandia</span>, and over $1 Billion for <span class=3DSpellE>A= ctos</span></b><span style=3Dmso-spacerun:yes>=FFFFFFA0 </span>-- despite = a number of drawbacks including potential liver toxicity.<span style=3Dmso= -spacerun:yes>=FFFFFFA0 </span>The success of these drugs demonstrates the= tremendous potential for an effective and safe insulin sensitizer such as= DIAB II.</span><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-s= ize:12.0pt;font-family:Arial><o:p></o:p></span></p><p class=3DMsoNormal st= yle=3Dtext-align:justify><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bi= di-font-size:10.0pt;font-family:Arial> </span><span lang=3DEN-CA styl= e=3Dfont-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial><o:p></o:p= ></span></p><p class=3DMsoNormal style=3Dtext-align:justify><b><span lang=3D= EN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>= The Potential Market: The market for Type II Diabetes drug worldwide is es= timated to be more than $10 billion annually.</span></b><span lang=3DEN-CA= style=3Dfont-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial><o:p>= </o:p></span></p><p class=3DMsoNormal style=3Dtext-align:justify><span lan= g=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Ar= ial> </span><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-= size:12.0pt;font-family:Arial><o:p></o:p></span></p><p class=3DMsoNormal s= tyle=3Dtext-align:justify><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-b= idi-font-size:10.0pt;font-family:Arial>Biotech=FFFFFF92s first goal is to = bring DIAB II onto the market in </span><st1:place><span lang=3DEN-CA styl= e=3D'font-size:9.0pt;mso-bidi-font-size:10.0pt;font-family: Arial'>Latin America</span></st1:place><span lang=3DEN-CA style=3D'font-si= ze: 9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial'>, as preparation for br= inging DIAB II to the drug market in the </span><st1:country-region><st1:p= lace><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font-size:10.0pt= ;font-family: Arial'>U.S.</span></st1:place></st1:country-region><span lang=3DEN-CA styl= e=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> and </spa= n><st1:country-region><st1:place><span lang=3DEN-CA style=3D'font-size:9.0= pt;mso-bidi-font-size:10.0pt;font-family: Arial'>Canada</span></st1:place></st1:country-region><span lang=3DEN-CA st= yle=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>. <b>Dis= cussions with potential pharmaceutical partners for the </b></span><st1:co= untry-region><st1:place><b><span lang=3DEN-CA style=3D'font-size:9.0pt;mso= -bidi-font-size:10.0pt;font-family: Arial'>U.S.</span></b></st1:place></st1:country-region><b><span lang=3DEN-= CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> ma= rket have begun.</span></b><span lang=3DEN-CA style=3D'font-size:9.0pt;mso= -bidi-font-size: 10.0pt;font-family:Arial'></span><span lang=3DEN-CA style=3D'font-size:9.0= pt; mso-bidi-font-size:12.0pt;font-family:Arial'><o:p></o:p></span></p><p clas= s=3DMsoNormal style=3Dtext-align:justify><span lang=3DEN-CA style=3Dfont-s= ize:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> </span><span l= ang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:= Arial><o:p></o:p></span></p><p class=3DMsoNormal style=3Dtext-align:justif= y><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;fon= t-family:Arial>In </span><st1:place><span lang=3DEN-CA style=3D'font-size:= 9.0pt;mso-bidi-font-size:10.0pt;font-family: Arial'>Latin America</span></st1:place><span lang=3DEN-CA style=3D'font-si= ze: 9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial'>, </span><st1:country-r= egion><st1:place><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font= -size:10.0pt;font-family: Arial'>Mexico</span></st1:place></st1:country-region><span lang=3DEN-CA st= yle=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> is firs= t on the company=FFFFFF92s list of target markets. In his report to shareh= olders issued </span><st1:date Month=3D3 Day=3D1 Year=3D2002><span lang=3D= EN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>= March 1, 2002</span></st1:date><span lang=3DEN-CA style=3D'font-size:9.0pt= ;mso-bidi-font-size: 10.0pt;font-family:Arial'>, the President of Biotech Holdings, Robert <spa= n class=3DSpellE>Rieveley</span>, said: <b>We believe that we are well pos= itioned for receiving regulatory approval shortly.<span style=3Dmso-spacer= un:yes>=FFFFFFA0 </span>Accordingly, we have been making preparations for = supply of DIAB II to the Mexican market, which is the eighth largest pharm= aceutical market in the world.</b></span><span lang=3DEN-CA style=3D'font-= size:9.0pt;mso-bidi-font-size: 12.0pt;font-family:Arial'><o:p></o:p></span></p><p class=3DMsoNormal style= =3Dtext-align:justify><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-= font-size:10.0pt;font-family:Arial> </span><span lang=3DEN-CA style=3D= font-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial><o:p></o:p></s= pan></p><p class=3DMsoNormal style=3Dtext-align:justify><span lang=3DEN-CA= style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>In </= span><st1:place><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font-= size:10.0pt;font-family: Arial'>Latin America</span></st1:place><span lang=3DEN-CA style=3D'font-si= ze: 9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial'>, DIAB II has already b= een approved in </span><st1:country-region><st1:place><span lang=3DEN-CA s= tyle=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>Peru</s= pan></st1:place></st1:country-region><span lang=3DEN-CA style=3Dfont-size:= 9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> and Biotech has signed = distribution agreements for </span><st1:country-region><st1:place><b><span= lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font-size:10.0pt;font-fami= ly: Arial'>Venezuela</span></b></st1:place></st1:country-region><b><span lang=3D= EN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>= , </span></b><st1:country-region><st1:place><b><span lang=3DEN-CA style=3D= font-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>Chile</span></= b></st1:place></st1:country-region><b><span lang=3DEN-CA style=3Dfont-size= :9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> and </span></b><st1:co= untry-region><st1:place><b><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-= bidi-font-size:10.0pt;font-family:Arial>Argentina</span></b></st1:place></= st1:country-region><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-fon= t-size:10.0pt;font-family:Arial>.<span style=3Dmso-spacerun:yes>=FFFFFFA0 = </span>In other markets, a distributor has been signed for </span><st1:cou= ntry-region><st1:place><b><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-b= idi-font-size:10.0pt;font-family:Arial>Turkey</span></b></st1:place></st1:= country-region><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-si= ze:10.0pt;font-family:Arial> and preliminary agreements are in place for <= /span><st1:country-region><st1:place><b><span lang=3DEN-CA style=3D'font-s= ize:9.0pt;mso-bidi-font-size:10.0pt;font-family: Arial'>Spain</span></b></st1:place></st1:country-region><b><span lang=3DEN= -CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>, = </span></b><st1:country-region><st1:place><b><span lang=3DEN-CA style=3Dfo= nt-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>Greece</span></b= ></st1:place></st1:country-region><b><span lang=3DEN-CA style=3Dfont-size:= 9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>, </span></b><st1:countr= y-region><st1:place><b><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi= -font-size:10.0pt;font-family:Arial>South Africa</span></b></st1:place></s= t1:country-region><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font= -size:10.0pt;font-family:Arial> and several markets in the </span><st1:pla= ce><span lang=3DEN-CA style=3D'font-size: 9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial'>Middle East</span></st1= :place><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0p= t;font-family:Arial> and </span><st1:place><span lang=3DEN-CA style=3D'fon= t-size:9.0pt;mso-bidi-font-size: 10.0pt;font-family:Arial'>South Asia</span></st1:place><span lang=3DEN-CA = style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>.</spa= n><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:12.0pt;fon= t-family:Arial><o:p></o:p></span></p><p class=3DMsoNormal style=3Dtext-ali= gn:justify><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:1= 0.0pt;font-family:Arial> </span><span lang=3DEN-CA style=3Dfont-size:= 9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial><o:p></o:p></span></p><p= class=3DMsoNormal style=3Dtext-align:justify><span lang=3DEN-CA style=3Df= ont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>The </span><st1= :country-region><st1:place><b><span lang=3DEN-CA style=3D'font-size:9.0pt;= mso-bidi-font-size:10.0pt;font-family: Arial'>U.S.</span></b></st1:place></st1:country-region><b><span lang=3DEN-= CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> pa= tents that protect DIAB II</span></b><span lang=3DEN-CA style=3D'font-size= :9.0pt;mso-bidi-font-size: 10.0pt;font-family:Arial'> - - issued on </span><st1:date Month=3D11 Day=3D= 28 Year=3D2000><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font-s= ize:10.0pt; font-family:Arial'>November 28, 2000</span></st1:date><span lang=3DEN-CA s= tyle=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial> and </= span><st1:date Month=3D9 Day=3D18 Year=3D2001><span lang=3DEN-CA style=3D'= font-size:9.0pt; mso-bidi-font-size:10.0pt;font-family:Arial'>September 18, 2001</span></st= 1:date><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0p= t;font-family:Arial> - - confer the sole right to the use of treatments co= mbining insulin-sensitizing drugs with any other standard medications for = Type II Diabetes.<span style=3Dmso-spacerun:yes>=FFFFFFA0 </span><b>Many l= arge pharmaceutical companies active in the diabetes field may be affected= </b></span><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:= 12.0pt;font-family:Arial><o:p></o:p></span></p><p class=3DMsoNormal style=3D= text-align:justify><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-fon= t-size:10.0pt;font-family:Arial> </span><span lang=3DEN-CA style=3Dfo= nt-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial><o:p></o:p></spa= n></p><p class=3DMsoNormal style=3Dtext-align:justify><span lang=3DEN-CA s= tyle=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>In addi= tion to its prescription drug business, Biotech has a non-prescription, pe= rsonal care products division which is showing steady growth.<span style=3D= mso-spacerun:yes>=FFFFFFA0 </span>In addition to its growing private label= business, this division is planning to launch a new line of high-margin c= osmetic products, which will be sold primarily in the </span><st1:country-= region><st1:place><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-fon= t-size:10.0pt;font-family: Arial'>U.S.</span></st1:place></st1:country-region><span lang=3DEN-CA styl= e=3Dfont-size:9.0pt;mso-bidi-font-size:12.0pt;font-family:Arial><o:p></o:p= ></span></p><p class=3DMsoNormal style=3Dtext-align:justify><span lang=3DE= N-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:10.0pt;font-family:Arial>&= nbsp;</span><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-font-size:= 12.0pt;font-family:Arial><o:p></o:p></span></p><p class=3DMsoNormal style=3D= text-align:justify><span lang=3DEN-CA style=3Dfont-size:9.0pt;mso-bidi-fon= t-size:10.0pt;font-family:Arial>Biotech=FFFFFF92s revenues are set to grow= sharply as <b>markets for DIAB II open up</b>, as <b>non-prescription rev= enues grow</b> and as the implications of the above-mentioned patents are = pursued, <b>with potential for royalty payments from major pharmaceutical = companies</b>. In his Report to Shareholders, the President of Biotech con= cluded: <b>We look forward with enthusiasm to developments in the coming m= onths.</b><b style=3Dmso-bidi-font-weight:normal><o:p></o:p></b></span></p= ><h1 align=3Dleft style=3Dtext-align:left><span lang=3DEN-CA style=3D'font= -family: "Calisto MT"'><o:p> </o:p></span></h1></td><td width=3D327 valign=3Dt= op style=3D'width:245.2pt;padding:0in 5.4pt 0in 5.4pt; height:549.0pt'><table class=3DMsoNormalTable border=3D0 cellspacing=3D0 c= ellpadding=3D0 align=3Dleft width=3D323 style=3D'width:242.6pt;border-coll= apse:collapse;mso-table-overlap: never;mso-table-lspace:9.0pt;margin-left:6.75pt;mso-table-rspace:9.0pt; margin-right:6.75pt;mso-table-anchor-vertical:paragraph;mso-table-anchor-h= orizontal: margin;mso-table-left:left;mso-table-top:97.8pt;mso-padding-alt:0in 5.4pt = 0in 5.4pt'><tr style=3Dmso-yfti-irow:0><td width=3D179 valign=3Dtop style=3D= 'width:134.6pt;border:solid windowtext 1.0pt; mso-border-alt:solid windowtext .5pt;background:green;padding:0in 5.4pt 0i= n 5.4pt'><p class=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0pt= ;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:white'>Company Name<o:p></o:= p></span></p></td><td width=3D144 valign=3Dtop style=3D'width:1.5in;border= :solid windowtext 1.0pt; border-left:none;mso-border-left-alt:solid windowtext .5pt;mso-border-alt: solid windowtext .5pt;background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p c= lass=3DMsoNormal><b><span lang=3DEN-CA style=3D'font-size:10.0pt;font-fami= ly: "Calisto MT";mso-bidi-font-family:Arial'>Biotech Holdings Ltd.<o:p></o:p><= /span></b></p></td></tr><tr style=3Dmso-yfti-irow:1><td width=3D179 valign= =3Dtop style=3D'width:134.6pt;border:solid windowtext 1.0pt; border-top:none;mso-border-left-alt:solid windowtext .5pt;mso-border-botto= m-alt: solid windowtext .5pt;mso-border-right-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal><span l= ang=3DEN-CA style=3D'font-size:10.0pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:white'>Stock Exchange in U.S= <o:p></o:p></span></p></td><td width=3D144 valign=3Dtop style=3D'width:1.5= in;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.= 0pt; mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowt= ext .5pt; mso-border-alt:solid windowtext .5pt;background:#E5D68D;padding:0in 5.4pt = 0in 5.4pt'><p class=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0= pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:black'>OTC BB: BIOHF</span><= span lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-b= idi-font-family: Arial'><o:p></o:p></span></p></td></tr><tr style=3Dmso-yfti-irow:2><td wid= th=3D179 valign=3Dtop style=3D'width:134.6pt;border:solid windowtext 1.0pt= ; border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt: solid windowtext .5pt;background:green;padding:0in 5.4pt 0in 5.4pt'><p cla= ss=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:white'>Stock Exchange in </s= pan><st1:country-region><st1:place><span lang=3DEN-CA style=3D'font-size:1= 0.0pt;font-family:"Calisto MT";mso-bidi-font-family: Arial;color:white'>Canada</span></st1:place></st1:country-region><span lan= g=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-font= -family: Arial;color:white'><o:p></o:p></span></p></td><td width=3D144 valign=3Dtop= style=3D'width:1.5in;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.= 0pt; mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowt= ext .5pt; mso-border-alt:solid windowtext .5pt;background:#E5D68D;padding:0in 5.4pt = 0in 5.4pt'><p class=3DMsoNormal><span class=3DSpellE><span lang=3DEN-CA st= yle=3D'font-size: 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial;color:black'>TS= X.Venture</span></span><span lang=3DEN-CA style=3D'font-size:10.0pt;font-f= amily:"Calisto MT";mso-bidi-font-family: Arial;color:black'>: BIO</span><span lang=3DEN-CA style=3D'font-size:10.0p= t; font-family:"Calisto MT";mso-bidi-font-family:Arial'><o:p></o:p></span></p= ></td></tr><tr style=3Dmso-yfti-irow:3><td width=3D179 valign=3Dtop style=3D= 'width:134.6pt;border:solid windowtext 1.0pt; border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt: solid windowtext .5pt;background:green;padding:0in 5.4pt 0in 5.4pt'><p cla= ss=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:white'>52-week High/Low BIOH= F<o:p></o:p></span></p></td><td width=3D144 valign=3Dtop style=3D'width:1.= 5in;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.= 0pt; mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowt= ext .5pt; mso-border-alt:solid windowtext .5pt;background:#E5D68D;padding:0in 5.4pt = 0in 5.4pt'><p class=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0= pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:black'>$.41/$0.07</span><spa= n lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi= -font-family: Arial'><o:p></o:p></span></p></td></tr><tr style=3Dmso-yfti-irow:4;mso-yft= i-lastrow:yes><td width=3D179 valign=3Dtop style=3D'width:134.6pt;border:s= olid windowtext 1.0pt; border-top:none;mso-border-top-alt:solid windowtext .5pt;mso-border-alt: solid windowtext .5pt;background:green;padding:0in 5.4pt 0in 5.4pt'><p cla= ss=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:white'>52-week High/Low BIO<= o:p></o:p></span></p></td><td width=3D144 valign=3Dtop style=3D'width:1.5i= n;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.= 0pt; mso-border-top-alt:solid windowtext .5pt;mso-border-left-alt:solid windowt= ext .5pt; mso-border-alt:solid windowtext .5pt;background:#E5D68D;padding:0in 5.4pt = 0in 5.4pt'><p class=3DMsoNormal><span lang=3DEN-CA style=3D'font-size:10.0= pt;font-family: "Calisto MT";mso-bidi-font-family:Arial;color:black'>$.65/$.12</span><span= lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-= font-family: Arial'><o:p></o:p></span></p></td></tr></table><p class=3DMsoNormal><span = lang=3DEN-CA><o:p> </o:p></span></p><p class=3DMsoNormal><span lang=3D= EN-CA><o:p> </o:p></span></p><p class=3DMsoNormal><span lang=3DEN-CA>= <o:p> </o:p></span></p><p class=3DMsoNormal><span lang=3DEN-CA><o:p>&= nbsp;</o:p></span></p><p class=3DMsoNormal><span lang=3DEN-CA><o:p> <= /o:p></span></p><p class=3DMsoNormal><span lang=3DEN-CA><o:p> </o:p><= /span></p><table class=3DMsoNormalTable border=3D0 cellspacing=3D0 cellpad= ding=3D0 style=3D'background:#E5D68D;border-collapse:collapse;mso-padding-= alt:0in 5.4pt 0in 5.4pt'><tr style=3Dmso-yfti-irow:0;mso-yfti-lastrow:yes>= <td width=3D324 valign=3Dtop style=3D'width:242.65pt;padding:0in 5.4pt 0in= 5.4pt'><h1 align=3Dleft style=3D'text-align:left;tab-stops:12.75pt center= 115.9pt'><span lang=3DEN-CA style=3D'font-family:"Calisto MT";color:green= '><span style=3Dmso-tab-count:2>=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFF= FA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA= 0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0 </span>THE </span><st1:place><span l= ang=3DEN-CA style=3D'font-family:"Calisto MT";color:green'>OPPORTUNITY</sp= an></st1:place><span lang=3DEN-CA style=3D'font-family:"Calisto MT";color:= green'><o:p></o:p></span></h1></td></tr></table><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 11.0pt;mso-bidi-font-size:12.0pt;font-family:"Calisto MT"'><o:p> </o:= p></span></p><h1 align=3Dcenter style=3Dtext-align:center><i><span lang=3D= EN-CA>There has been growing investor interest and substantial volumes in = trading of BIOHF shares.<span style=3Dmso-spacerun:yes>=FFFFFFA0 </span>Si= nce January 2002 trading has averaged nearly 1 million shares per week.<sp= an style=3Dmso-spacerun:yes>=FFFFFFA0 </span>This suggests to some market = watchers that a strong base is being formed, with the next step being a si= gnificant upward movement.<span style=3Dmso-spacerun:yes>=FFFFFFA0=FFFFFFA= 0 </span>Research the growth potential of this special situation while the= Company that developed, controls and markets DIAB II is still trading as = a penny stock.<o:p></o:p></span></i></h1><p class=3DMsoNormal><span lang=3D= EN-CA><o:p> </o:p></span></p><p class=3DMsoNormal><span lang=3DEN-CA>= <o:p> </o:p></span></p><table class=3DMsoNormalTable border=3D0 cells= pacing=3D0 cellpadding=3D0 style=3D'background:#E5D68D;border-collapse:col= lapse;mso-padding-alt:0in 5.4pt 0in 5.4pt'><tr style=3Dmso-yfti-irow:0;mso= -yfti-lastrow:yes><td width=3D324 valign=3Dtop style=3D'width:242.65pt;pad= ding:0in 5.4pt 0in 5.4pt'><h2 align=3Dcenter style=3Dtext-align:center><sp= an lang=3DEN-CA style=3D'font-family:"Calisto MT";color:green'>INVESTOR IN= FORMATION</span><span lang=3DEN-CA style=3Dcolor:green><o:p></o:p></span><= /h2></td></tr></table><p class=3DMsoNormal><b><span lang=3DEN-CA style=3D'= font-family:"Calisto MT"; color:black'><o:p> </o:p></span></b></p><table class=3DMsoNormalTable= border=3D0 cellspacing=3D0 cellpadding=3D0 width=3D332 style=3D'width:249= 0pt;border-collapse:collapse;mso-padding-alt:0in 5.4pt 0in 5.4pt'><tr sty= le=3Dmso-yfti-irow:0><td width=3D192 valign=3Dtop style=3D'width:144.2pt;b= order:none;border-bottom: solid windowtext 1.0pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:10.= 0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:white'>Active Float:</span><span lang=3DEN-CA style=3D'font-size:10.= 0pt; mso-bidi-font-size:12.0pt;color:white'><o:p></o:p></span></p></td><td widt= h=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;border-bottom: solid windowtext 1.0pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:black'>20,000,000</span><span lang=3DEN-CA style=3D'font-size:10.0pt= ; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr><tr style=3Dmso= -yfti-irow:1><td width=3D192 valign=3Dtop style=3D'width:144.2pt;border:no= ne;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><st1:country-region><st1:place><span lang= =3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-font-= family: Arial;color:white'>U.S.</span></st1:place></st1:country-region><span lang=3D= EN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-font-fam= ily: Arial;color:white'> SEC Registration No.:</span><span lang=3DEN-CA style=3D= font-size:10.0pt;mso-bidi-font-size:12.0pt;color:white><o:p></o:p></span><= /p></td><td width=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;bo= rder-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:black'>0 - 29108</span><span lang=3DEN-CA style=3D'font-size:10.0pt; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr><tr style=3Dmso= -yfti-irow:2><td width=3D192 valign=3Dtop style=3D'width:144.2pt;border:no= ne;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:10.= 0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:white'>Shares outstandingMar.31/02:</span><span lang=3DEN-CA style=3D= font-size:10.0pt;mso-bidi-font-size:12.0pt;color:white><o:p></o:p></span><= /p></td><td width=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;bo= rder-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:black'>69,928,130</span><span lang=3DEN-CA style=3D'font-size:10.0pt= ; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr><tr style=3Dmso= -yfti-irow:3><td width=3D192 valign=3Dtop style=3D'width:144.2pt;border:no= ne;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:10.= 0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:white'>Recent Market Cap:</span><span lang=3DEN-CA style=3D'font-siz= e: 10.0pt;mso-bidi-font-size:12.0pt;color:white'><o:p></o:p></span></p></td><= td width=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;border-bott= om: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:black'>$6,300,000 US</span><span lang=3DEN-CA style=3D'font-size:10.= 0pt; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr><tr style=3Dmso= -yfti-irow:4><td width=3D192 valign=3Dtop style=3D'width:144.2pt;border:no= ne;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:10.= 0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:white'>Stock Exchange in </span><st1:country-region><st1:place><span= lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-= font-family: Arial;color:white'>U.S.</span></st1:place></st1:country-region><span lang=3D= EN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-font-fam= ily: Arial;color:white'>:</span><span lang=3DEN-CA style=3D'font-size:10.0pt; mso-bidi-font-size:12.0pt;color:white'><o:p></o:p></span></p></td><td widt= h=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:black'>OTC BB: BIOHF</span><span lang=3DEN-CA style=3D'font-size:10.= 0pt; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr><tr style=3Dmso= -yfti-irow:5><td width=3D192 valign=3Dtop style=3D'width:144.2pt;border:no= ne;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:10.= 0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:white'>Stock Exchange in </span><st1:country-region><st1:place><span= lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-= font-family: Arial;color:white'>Canada</span></st1:place></st1:country-region><span lan= g=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";mso-bidi-font= -family: Arial;color:white'>:</span><span lang=3DEN-CA style=3D'font-size:10.0pt; mso-bidi-font-size:12.0pt;color:white'><o:p></o:p></span></p></td><td widt= h=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span class=3DSpellE><span lang=3DEN-C= A style=3D'font-size:10.0pt;font-family:"Calisto MT"; mso-bidi-font-family:Arial;color:black'>TSX.Venture:BIO</span></span><span= lang=3DEN-CA style=3Dfont-size:10.0pt;mso-bidi-font-size:12.0pt><o:p></o:= p></span></p></td></tr><tr style=3Dmso-yfti-irow:6><td width=3D192 valign=3D= top style=3D'width:144.2pt;border:none;border-bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:green;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align=3D= center style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:10.= 0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:white'>52-week High/Low BIOHF:</span><span lang=3DEN-CA style=3Dfont= -size:10.0pt;mso-bidi-font-size:12.0pt;color:white><o:p></o:p></span></p><= /td><td width=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;border= -bottom: solid windowtext 1.0pt;mso-border-top-alt:solid windowtext .5pt;mso-border= -top-alt: solid windowtext .5pt;mso-border-bottom-alt:solid windowtext .5pt; background:#E5D68D;padding:0in 5.4pt 0in 5.4pt'><p class=3DMsoNormal align= =3Dcenter style=3Dtext-align:center><span lang=3DEN-CA style=3D'font-size:= 10.0pt;font-family:"Calisto MT";mso-bidi-font-family:Arial; color:black'>$.41/$0.07</span><span lang=3DEN-CA style=3D'font-size:10.0pt= ; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr><tr style=3Dmso= -yfti-irow:7;mso-yfti-lastrow:yes;height:3.5pt><td width=3D192 valign=3Dto= p style=3D'width:144.2pt;border:none;mso-border-top-alt: solid windowtext .5pt;background:green;padding:0in 5.4pt 0in 5.4pt; height:3.5pt'><p class=3DMsoNormal align=3Dcenter style=3Dtext-align:cente= r><span lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";ms= o-bidi-font-family:Arial; color:white'>52-week High/Low BIO:</span><span lang=3DEN-CA style=3D'font-= size: 10.0pt;mso-bidi-font-size:12.0pt;color:white'><o:p></o:p></span></p></td><= td width=3D140 valign=3Dtop style=3D'width:104.8pt;border:none;mso-border-= top-alt: solid windowtext .5pt;background:#E5D68D;padding:0in 5.4pt 0in 5.4pt; height:3.5pt'><p class=3DMsoNormal align=3Dcenter style=3Dtext-align:cente= r><span lang=3DEN-CA style=3D'font-size:10.0pt;font-family:"Calisto MT";ms= o-bidi-font-family:Arial; color:black'>$.65/$.12</span><span lang=3DEN-CA style=3D'font-size:10.0pt; mso-bidi-font-size:12.0pt'><o:p></o:p></span></p></td></tr></table><p clas= s=3DMsoNormal align=3Dcenter style=3Dtext-align:center><b><span lang=3DEN-= CA style=3D'font-family:"Calisto MT";color:black'><o:p> </o:p></span>= </b></p><p class=3DMsoNormal style=3Dtab-stops:2.25in><b><span lang=3DEN-C= A style=3D'font-family:"Calisto MT";color:black'><span style=3Dmso-tab-cou= nt:1>=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFF= FA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA= 0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FF= FFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFF= FFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFF= A0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0= =FFFFFFA0=FFFFFFA0=FFFFFFA0=FFFFFFA0</span></span></b></p></td></tr></tabl= e><p class=3DMsoBodyText2 style=3Dtext-align:justify><span lang=3DEN-CA>Th= e Investment Journal: The information herein has been obtained from source= s which are believed to be reliable, but there are no guarantees as to its= accuracy or completeness. Neither the information nor any opinion express= ed constitutes a solicitation for the purchase or sale of any security. Bi= otech Holdings has not paid any cash or shares for its appearance on this = report.<span style=3Dmso-spacerun:yes>=FFFFFFA0 </span>Some or all employe= es at The Investment Journal may hold shares in companies featured. We do = not recommend or constitute "buy" or "sell" signals or= advisories for our readers. The Investment Journal is not a securities br= oker-dealer, investment advisor or a securities exchange and is not regist= ered as such with the Securities and Exchange Commission <span class=3DGra= mE>nor</span> any state securities regulation authority. Consult with your= financial advisor before making any financial decisions.</span></p><p cla= ss=3DMsoNormal align=3Dcenter style=3Dtext-align:center><b style=3D'mso-bi= di-font-weight: normal'><span lang=3DEN-CA style=3Dfont-size:7.5pt>This Newsletter is inte= nded for our opt-in readers only. If you have received this email in error= ,<o:p></o:p></span></b></p><p class=3DMsoNormal align=3Dcenter style=3Dtex= t-align:center><b style=3D'mso-bidi-font-weight: normal'><span lang=3DEN-CA style=3Dfont-size:7.5pt><span style=3Dmso-space= run:yes>=FFFFFFA0</span></span></b><span class=3DGramE><b style=3Dmso-bidi= -font-weight:normal><span lang=3DEN-CA style=3D'font-size:7.5pt; mso-bidi-font-size:12.0pt'>you</span></b></span><b style=3D'mso-bidi-font-= weight: normal'><span lang=3DEN-CA style=3Dfont-size:7.5pt;mso-bidi-font-size:12.0= pt> may remove your address by </span></b><b style=3Dmso-bidi-font-weight:= normal><span lang=3DEN-CA style=3Dfont-size:7.5pt>e-mailing</span></b><b s= tyle=3D'mso-bidi-font-weight: normal'><span lang=3DEN-CA style=3D'font-size:9.0pt;mso-bidi-font-size:12.= 0pt; font-family:Arial'>  </span></b><b style=3Dmso-bidi-font-weight:norma= l><span lang=3DEN-CA style=3Dfont-size:8.0pt;mso-bidi-font-size:12.0pt><a = href=3Dmailto:theinvestmentjournal@excite.com?subject=3DRemove>theinvestme= ntjournal@excite.com</a>.</span></b><b style=3Dmso-bidi-font-weight:normal= ><span lang=3DEN-CA style=3D'font-size:9.0pt; mso-bidi-font-size:12.0pt;font-family:Arial'><o:p></o:p></span></b></p><p = class=3DMsoNormal><b><span lang=3DEN-CA style=3D'font-size:36.0pt;mso-bidi= -font-size: 12.0pt;font-family:Algerian;color:green'><o:p> </o:p></span></b></p><= /div></body></html>