I use

#+LATEX_HEADER: \usepackage[citestyle=authoryear-icomp,bibstyle=authoryear,hyperref=true,backref=true,maxcitenames=3,url=true,backend=biber,natbib=true]{biblatex}

Can you try this, and if it works, modify as you prefer.

Also, as Leonard suggested, I would create a tex file, and work on it from the terminal to see what is wrong.

Compile the tex file, run biber and then compile the tex file again. This would help identify what is wrong.

Vikas