Hello, Python.el has this text: " ;; Running IPython on Windows needs more tweaking. The way you should ;; set `python-shell-interpreter' and `python-shell-interpreter-args' ;; is as follows (of course you need to modify the paths according to ;; your system): ;; (setq python-shell-interpreter "C:\\Python27\\python.exe" ;; python-shell-interpreter-args ;; "-i C:\\Python27\\Scripts\\ipython-script.py") " I uncommented the code, but got an error saying " error: Non-hex digit used for Unicode escape." Found out from here ( https://stackoverflow.com/questions/24666816/emacs-warning-an-error-occurred-while-loading-emacs-el ) that emacs on Windows knows to turn forward slashes into backslashes. Edited it to be like this: (defcustom python-shell-interpreter "C:/Users/Matt/Anaconda/python.exe" "Default Python interpreter for shell." :type 'string :group 'python) (defcustom python-shell-interpreter-args "-i C:/Users/Matt/Anaconda/Scripts/ipython-script.py" "Default arguments for the Python interpreter." :type 'string :group 'python) And it worked! Maybe change the warning in python.el? Thanks, Matt In GNU Emacs 25.0.50.1 (x86_64-w64-mingw32) of 2015-08-18 on KAEL Repository revision: 07ebe42546abbc9823c9ce3c7b2e397b551838a1 Windowing system distributor `Microsoft Corp.', version 6.3.9600 Configured using: `configure --prefix=/z/emacs --host=x86_64-w64-mingw32 --target=x86_64-w64-mingw32 --build=x86_64-w64-mingw32 --with-wide-int --with-jpeg --with-xpm --with-png --with-tiff --with-rsvg --with-xml2 --with-gnutls --with-sound=yes --with-file-notification=yes --without-dbus --without-imagemagick 'CFLAGS=-O3 -fomit-frame-pointer -g0 -pipe' 'LDFLAGS=-static-libgcc -static-libstdc++ -static -s -Wl,-s'' Configured features: XPM JPEG TIFF GIF PNG RSVG SOUND NOTIFY ACL GNUTLS LIBXML2 ZLIB TOOLKIT_SCROLL_BARS Important settings: value of $LANG: ENU locale-coding-system: cp1252 Major mode: Emacs-Lisp Minor modes in effect: helm-descbinds-mode: t helm-mode: t shell-dirtrack-mode: t projectile-global-mode: t projectile-mode: t recentf-mode: t highlight-parentheses-mode: t rainbow-delimiters-mode: t yas-global-mode: t yas-minor-mode: t winner-mode: t window-numbering-mode: t volatile-highlights-mode: t global-vi-tilde-fringe-mode: t vi-tilde-fringe-mode: t global-undo-tree-mode: t undo-tree-mode: t savehist-mode: t popwin-mode: t global-page-break-lines-mode: t page-break-lines-mode: t Info-breadcrumbs-in-mode-line-mode: t ido-vertical-mode: t flx-ido-mode: t global-evil-surround-mode: t evil-surround-mode: t global-evil-search-highlight-persist: t evil-search-highlight-persist: t show-smartparens-global-mode: t show-smartparens-mode: t smartparens-mode: t evil-jumper-mode: t evil-escape-mode: t global-anzu-mode: t anzu-mode: t eval-sexp-fu-flash-mode: t global-diff-hl-mode: t diff-hl-mode: t global-hl-line-mode: t xterm-mouse-mode: t global-auto-revert-mode: t evil-leader-mode: t evil-mode: t evil-local-mode: t which-key-mode: t override-global-mode: t diff-auto-refine-mode: t spacemacs-additional-leader-mode: t global-eldoc-mode: t electric-indent-mode: t mouse-wheel-mode: t file-name-shadow-mode: t global-font-lock-mode: t font-lock-mode: t auto-composition-mode: t auto-encryption-mode: t auto-compression-mode: t column-number-mode: t line-number-mode: t transient-mark-mode: t hs-minor-mode: t Recent messages: user-error: Please specify a file name for the buffer Saving file c:/Program Files/emacs/share/emacs/25.0.50/lisp/progmodes/python.el... Wrote c:/Program Files/emacs/share/emacs/25.0.50/lisp/progmodes/python.el Compiling c:/Program Files/emacs/share/emacs/25.0.50/lisp/progmodes/python.el...done Wrote c:/Program Files/emacs/share/emacs/25.0.50/lisp/progmodes/python.elc Mark saved where search started [2 times] Mark set Mark saved where search started [2 times] interpreter-mode-alist: Alist mapping interpreter names to major modes. Invalid face reference: t [15 times] Load-path shadows: c:/Users/Matt/AppData/Roaming/.emacs.d/elpa/helm-20151006.1001/helm-multi-match hides c:/Users/Matt/AppData/Roaming/.emacs.d/elpa/helm-core-20151004.958/helm-multi-match c:/Users/Matt/AppData/Roaming/.emacs.d/elpa/seq-20150928.1218/seq hides c:/Program Files/emacs/share/emacs/25.0.50/lisp/emacs-lisp/seq Features: (shadow mail-extr emacsbug message rfc822 mml mml-sec mailabbrev gmm-utils mailheader sendmail mail-utils helm-command helm-elisp helm-eval edebug sort skeleton tramp-sh misearch multi-isearch helm-descbinds helm-mode helm-files image-dired tramp tramp-compat tramp-loaddefs trampver shell pcomplete format-spec dired-x dired-aux ffap helm-buffers helm-elscreen helm-tags helm-bookmark helm-adaptive helm-info bookmark helm-locate helm-grep helm-regexp helm-plugin helm-external helm-net browse-url xml url url-proxy url-privacy url-expand url-methods url-history url-cookie url-domsuf url-util mailcap helm-utils helm-help helm-types helm helm-source eieio-compat helm-multi-match helm-lib dired find-func async projectile grep compile ibuf-ext ibuffer recentf tree-widget highlight-parentheses hideshow rainbow-delimiters yasnippet server winner window-numbering etags xref project volatile-highlights vi-tilde-fringe undo-tree diff smooth-scrolling smartparens-config saveplace savehist py-yapf powerline powerline-separators color powerline-themes popwin page-break-lines info+ ido-vertical-mode flx-ido flx ido exec-path-from-shell evil-surround evil-search-highlight-persist evil-numbers evil-lisp-state smartparens evil-jumper evil-indent-textobject evil-exchange evil-escape evil-args evil-anzu anzu info cider-eval-sexp-fu eval-sexp-fu rx highlight diminish diff-hl vc-dir ewoc vc vc-dispatcher company-web company web-completion-data adaptive-wrap hybrid-mode ielm pp comint ansi-color hl-line xt-mouse autorevert filenotify core-evilified-state evil-leader evil evil-integration evil-maps evil-commands evil-command-window evil-types evil-search evil-ex evil-macros evil-repeat evil-states evil-core evil-common windmove thingatpt rect evil-digraphs evil-vars ring which-key quelpa url-parse auth-source gnus-util password-cache url-vars package-build mm-decode mm-bodies mm-encode mail-parse rfc2231 rfc2047 rfc2045 ietf-drums mm-util help-fns mail-prsvr json lisp-mnt use-package bind-key s ucs-normalize vc-git diff-mode wid-edit solarized-dark-theme solarized dash core-configuration-layer cl-seq finder-inf core-dotspacemacs ht cl warnings package epg-config eieio byte-opt bytecomp byte-compile cl-extra help-mode easymenu seq cconv eieio-core cl-macs gv core-spacemacs derived edmacro kmacro cl-loaddefs cl-lib core-keybindings easy-mmode core-use-package-ext core-micro-state corelv core-toggle core-fonts-support core-spacemacs-buffer core-funcs core-themes-support advice core-auto-completion core-release-management core-emacs-backports subr-x pcase time-date mule-util tooltip eldoc electric uniquify ediff-hook vc-hooks lisp-float-type mwheel dos-w32 ls-lisp disp-table w32-win w32-vars term/common-win tool-bar dnd fontset image regexp-opt fringe tabulated-list newcomment elisp-mode lisp-mode prog-mode register page menu-bar rfn-eshadow timer select scroll-bar mouse jit-lock font-lock syntax facemenu font-core frame cl-generic cham georgian utf-8-lang misc-lang vietnamese tibetan thai tai-viet lao korean japanese eucjp-ms cp51932 hebrew greek romanian slovak czech european ethiopic indian cyrillic chinese charscript case-table epa-hook jka-cmpr-hook help simple abbrev minibuffer cl-preloaded nadvice loaddefs button faces cus-face macroexp files text-properties overlay sha1 md5 base64 format env code-pages mule custom widget hashtable-print-readable backquote w32notify w32 multi-tty make-network-process emacs) Memory information: ((conses 16 795718 736194) (symbols 56 48097 17) (miscs 48 535 1402) (strings 32 96795 260046) (string-bytes 1 3028696) (vectors 16 82878) (vector-slots 8 2024527 372434) (floats 8 1011 1610) (intervals 56 5724 3812) (buffers 976 19))