On start-up of emacs, the .emacs file could not be loaded, because emacs resolved the Windows HOME variable to *exactly* how it was defined. That was the text %HOMEDRIVE%%HOMEPATH%. Emacs could not resolve these two variables. The workaround for me was to manually change the HOME variable to the absolute path (and to resolve the two variables %HOMEDRIVE% and %HOMEPATH% and restart windows. In GNU Emacs 24.5.1 (i686-pc-mingw32) of 2015-04-11 on LEG570 Windowing system distributor `Microsoft Corp.', version 6.1.7601 Configured using: `configure --prefix=/c/usr --host=i686-pc-mingw32' Important settings: value of $LANG: DEU locale-coding-system: cp1252 Major mode: Fundamental Minor modes in effect: tooltip-mode: t electric-indent-mode: t mouse-wheel-mode: t tool-bar-mode: t menu-bar-mode: t file-name-shadow-mode: t global-font-lock-mode: t blink-cursor-mode: t auto-composition-mode: t auto-encryption-mode: t auto-compression-mode: t buffer-read-only: t line-number-mode: t transient-mark-mode: t Recent messages: For information about GNU Emacs and the GNU system, type C-h C-a. Load-path shadows: None found. Features: (shadow sort gnus-util mail-extr emacsbug message format-spec rfc822 mml easymenu mml-sec mm-decode mm-bodies mm-encode mail-parse rfc2231 mailabbrev gmm-utils mailheader sendmail rfc2047 rfc2045 ietf-drums mm-util help-fns mail-prsvr mail-utils time-date tooltip electric uniquify ediff-hook vc-hooks lisp-float-type mwheel dos-w32 ls-lisp w32-common-fns disp-table w32-win w32-vars tool-bar dnd fontset image regexp-opt fringe tabulated-list newcomment lisp-mode prog-mode register page menu-bar rfn-eshadow timer select scroll-bar mouse jit-lock font-lock syntax facemenu font-core frame cham georgian utf-8-lang misc-lang vietnamese tibetan thai tai-viet lao korean japanese hebrew greek romanian slovak czech european ethiopic indian cyrillic chinese case-table epa-hook jka-cmpr-hook help simple abbrev minibuffer nadvice loaddefs button faces cus-face macroexp files text-properties overlay sha1 md5 base64 format env code-pages mule custom widget hashtable-print-readable backquote make-network-process w32notify w32 multi-tty emacs) Memory information: ((conses 8 75908 6759) (symbols 32 17433 0) (miscs 32 73 127) (strings 16 10713 4029) (string-bytes 1 279807) (vectors 8 8926) (vector-slots 4 382520 5128) (floats 8 56 203) (intervals 28 246 36) (buffers 508 13))