Thanks for the quick response.
My set up of python path in .emacs is:
(setq python-shell-interpreter "C:\\Python27\\Scripts\\ipython")
(setq python-shell-interpreter-args "-i --profile=dev --colors=Linux")

Da

On 3/31/2015 2:24 PM, Eli Zaretskii wrote:

Date: Tue, 31 Mar 2015 13:52:20 -0400
From: Da Zhang <zhangda82@gmail.com>

I am using Python mode in Emacs and wanted to start a python
sub-process.
However, Emacs could not find python.exe from the path I specified.
Particularly, the following message was displayed:
apply: Searching for program: no such file or directory,
c\:/Python27/Scripts/ipython.exeInvalid face reference: python-cell

It seemed a "C\:" was added in front of the path to the python.

You didn't say which path of Python did you specify, and how didyou
specify it.  Please tell, otherwise it's very hard to figure out the
reason for the problem.