Perhaps try to use more the features which require signals, like
profiler and sub-processes?

Sounds good, will do.

I ran the profiler for a short while a few days ago and saw no issues. I’ll try to experiment with subprocesses.

Also, if you are used to start Emacs anew frequently, try instead to
leave a session running for a long time (and use emacsclient for
one-off jobs, if you need that).

Yeah, I typically favor long-running sessions. I’ll try to avoid unnecessary restarts.

TIA