diff --git a/doc/misc/url.texi b/doc/misc/url.texi
index 8f15e11007..2ea34e0d03 100644
--- a/doc/misc/url.texi
+++ b/doc/misc/url.texi
@@ -923,6 +923,12 @@ Disk Caching
 expire-time argument of the function @code{url-cache-expired}.
 @end defopt
 
+@defopt url-cache-expiry-alist
+This variable is an alist of regular expressions matching @var{url}'s
+and their associated expiration delay in seconds.  It is used by the
+functions @code{url-cache-expired} and @code{url-cache-prune-cache}.
+@end defopt
+
 @defun url-fetch-from-cache
 This function takes a URL as its argument and returns a buffer
 containing the data cached for that URL.
diff --git a/lisp/url/url-cache.el b/lisp/url/url-cache.el
index 830e6ba9dc..48f315a5cc 100644
--- a/lisp/url/url-cache.el
+++ b/lisp/url/url-cache.el
@@ -38,6 +38,15 @@ url-cache-expire-time
   :type 'integer
   :group 'url-cache)
 
+(defcustom url-cache-expiry-alist nil
+  "Alist of URL regular expressions to override the `url-cache-expire-time'.
+The key is a string to be matched against the URL of the cached entry and the
+value is the expire time in seconds.  Only the protocol and hostname of the URL
+are available for matching."
+  :version "28.1"
+  :type 'alist
+  :group 'url-cache)
+
 ;; Cache manager
 (defun url-cache-file-writable-p (file)
   "Follows the documentation of `file-writable-p', unlike `file-writable-p'."
@@ -186,6 +195,31 @@ url-cache-create-filename
             (if (url-p url) url
               (url-generic-parse-url url)))))
 
+(defun url-cache-create-url-from-file (file)
+  (let* ((url-path-list
+	  (split-string
+	   (file-name-directory
+	    (string-trim-left file (concat "^.*/" (user-real-login-name))))
+	    "/" t))
+	 (protocol (pop url-path-list))
+	 (hostname
+	  (string-join (reverse url-path-list) "."))
+	 (url (string-join (list protocol hostname) "://")))
+    url))
+
+(defun url-cache-expiry-by-url (url)
+  (let ((expire-time
+	 (remove nil
+		 (mapcar
+		  (lambda (alist)
+		    (let ((key (car alist))
+			  (value (cdr alist)))
+		      (if (string-match
+			   key url)
+			  value)))
+		  url-cache-expiry-alist))))
+    (if (consp expire-time) (apply 'min expire-time) nil)))
+
 ;;;###autoload
 (defun url-cache-extract (fnam)
   "Extract FNAM from the local disk cache."
@@ -204,7 +238,9 @@ url-cache-expired
 	  (time-less-p
 	   (time-add
 	    cache-time
-	    (or expire-time url-cache-expire-time))
+	    (or expire-time
+		(url-cache-expiry-by-url url)
+		url-cache-expire-time))
 	   nil)))))
 
 (defun url-cache-prune-cache (&optional directory)
@@ -226,8 +262,10 @@ url-cache-prune-cache
 	   ((time-less-p
 	     (time-add
 	      (file-attribute-modification-time (file-attributes file))
-	      url-cache-expire-time)
-	     now)
+	      (or (url-cache-expiry-by-url
+		   (url-cache-create-url-from-file file))
+		  url-cache-expire-time))
+	      now)
 	    (delete-file file)
 	    (setq deleted-files (1+ deleted-files))))))
       (if (< deleted-files total-files)
diff --git a/test/lisp/url/url-cache-tests.el b/test/lisp/url/url-cache-tests.el
new file mode 100644
index 0000000000..f4e49ce3b9
--- /dev/null
+++ b/test/lisp/url/url-cache-tests.el
@@ -0,0 +1,76 @@
+;;; url-cache-tests.el --- Test suite for url-cache.  -*- lexical-binding:t -*-
+
+;; Copyright (C) 2021 Free Software Foundation, Inc.
+
+;; Author: Alex Bochannek <alex@bochannek.com>
+;; Keywords: data
+
+;; This file is part of GNU Emacs.
+
+;; GNU Emacs is free software: you can redistribute it and/or modify
+;; it under the terms of the GNU General Public License as published by
+;; the Free Software Foundation, either version 3 of the License, or
+;; (at your option) any later version.
+
+;; GNU Emacs is distributed in the hope that it will be useful,
+;; but WITHOUT ANY WARRANTY; without even the implied warranty of
+;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.	 See the
+;; GNU General Public License for more details.
+
+;; You should have received a copy of the GNU General Public License
+;; along with GNU Emacs.  If not, see <https://www.gnu.org/licenses/>.
+
+;;; Code:
+
+(require 'ert)
+(require 'url-cache)
+
+(ert-deftest url-cache-url-to-filename-tests ()
+  "Test the URL to filename resolution for the URL cache"
+  (should (equal (file-name-directory
+		  (url-cache-create-filename "http://www.fsf.co.uk"))
+		 (string-join
+		  (list url-cache-directory (user-real-login-name)
+			"http/uk/co/fsf/www/") "/")))
+  (should (equal (file-name-directory
+		  (url-cache-create-filename "https://www.fsf.co.uk"))
+		 (string-join
+		  (list url-cache-directory (user-real-login-name)
+			"https/uk/co/fsf/www/") "/")))
+  (should (equal (file-name-directory
+		  (url-cache-create-filename "http://host"))
+		 (string-join
+		  (list url-cache-directory (user-real-login-name)
+			"http/host/") "/")))
+  (should (equal (file-name-directory
+		  (url-cache-create-filename "http://host:80"))
+		 (string-join
+		  (list url-cache-directory (user-real-login-name)
+			"http/host/") "/")))
+  (should (equal (file-name-directory
+		  (url-cache-create-filename "http://host#fragment"))
+		 (string-join
+		  (list url-cache-directory (user-real-login-name)
+			"http/host/") "/"))))
+
+(ert-deftest url-cache-filename-to-url-tests ()
+  "Test the filename to URL resolution for the URL cache"
+  (should (equal (url-cache-create-url-from-file
+		  (string-join
+		   (list url-cache-directory (user-real-login-name)
+			 "http/uk/co/fsf/www/") "/"))
+		 "http://www.fsf.co.uk"))
+  (should (equal (url-cache-create-url-from-file
+		  (string-join
+		   (list url-cache-directory (user-real-login-name)
+			 "https/uk/co/fsf/www/") "/"))
+		 "https://www.fsf.co.uk"))
+  (should (equal (url-cache-create-url-from-file
+		  (string-join
+		   (list url-cache-directory (user-real-login-name)
+			 "http/host/") "/"))
+		 "http://host")))
+
+(provide 'url-cache-tests)
+
+;;; url-cache-tests.el ends here