$ emacs -Q /usr/share/dict/words
C-SPC
M->
^X^X .....
(beep) Timed out waiting for property-notify event
You can recover by hitting ^G several times.
Problem appears when the transient-mark encloses a large region. Does not occur in a terminal window (i.e., emacs -Q -nw). Appears to be an x-selection issue.