Hi, I'm not an expert in how python.el internals work, but I started getting this error every time I would send a statement to the shell. In addition I would get these weird printouts of blocks of the form ``` def __PYDOC_get_help(obj): try: import inspect try: str_type = basestring argspec_function = inspect.getargspec except NameError: str_type = str ``` while just moving the point in my .py file. My current workaround was to simply override python-shell-send-string from 28.0.50 with the one I had with my emacs 27 version, which was: ``` (defun python-shell-send-string (string &optional process msg) "Send STRING to inferior Python PROCESS. When optional argument MSG is non-nil, forces display of a user-friendly message if there's no process running; defaults to t when called interactively." (interactive (list (read-string "Python command: ") nil t)) (let ((process (or process (python-shell-get-process-or-error msg)))) (if (string-match ".\n+." string) ;Multiline. (let* ((temp-file-name (python-shell--save-temp-file string)) (file-name (or (buffer-file-name) temp-file-name))) (python-shell-send-file file-name process temp-file-name t)) (when (or (not (string-match "\n\\'" string)) (string-match "\n[ \t].*\n?\\'" string)) (comint-send-string process "\n"))))) ``` And this seems to solve the problem... In GNU Emacs 28.0.50 (build 1, x86_64-apple-darwin20.6.0, NS appkit-2022.60 Version 11.6 (Build 20G165)) of 2021-09-17 built on mdfz-macbookpro4.roam.corp.google.com Windowing system distributor 'Apple', version 10.3.2022 System Description: macOS 11.6 Configured using: 'configure --disable-dependency-tracking --disable-silent-rules --enable-locallisppath=/usr/local/share/emacs/site-lisp --infodir=/usr/local/Cellar/emacs-plus@28/28.0.50/share/info/emacs --prefix=/usr/local/Cellar/emacs-plus@28/28.0.50 --with-xml2 --with-gnutls --without-dbus --with-imagemagick --with-modules --with-rsvg --with-ns --disable-ns-self-contained' Configured features: ACL GLIB GMP GNUTLS IMAGEMAGICK JPEG JSON LCMS2 LIBXML2 MODULES NOTIFY KQUEUE NS PDUMPER PNG RSVG THREADS TIFF TOOLKIT_SCROLL_BARS XIM ZLIB Important settings: value of $LC_ALL: en_US.UTF-8 value of $LC_CTYPE: en_US.UTF-8 value of $LANG: en_US.UTF-8 locale-coding-system: utf-8-unix Major mode: mu4e-headers Memory information: ((conses 16 1905022 1639005) (symbols 48 123242 97) (strings 32 433582 151543) (string-bytes 1 14825386) (vectors 16 192606) (vector-slots 8 3165377 831342) (floats 8 1100 6586) (intervals 56 34684 19693) (buffers 992 60))