diff --git a/lisp/subr.el b/lisp/subr.el
index 4b75268c04..7f1450d4a2 100644
--- a/lisp/subr.el
+++ b/lisp/subr.el
@@ -2745,20 +2746,22 @@ read-char-from-minibuffer-insert-char
   "Insert the character you type in the minibuffer and exit.
 Discard all previous input before inserting and exiting the minibuffer."
   (interactive)
-  (delete-minibuffer-contents)
-  (insert last-command-event)
-  (exit-minibuffer))
+  (when (minibufferp)
+    (delete-minibuffer-contents)
+    (insert last-command-event)
+    (exit-minibuffer)))
 
 (defun read-char-from-minibuffer-insert-other ()
   "Handle inserting of a character other than allowed.
 Display an error on trying to insert a disallowed character.
 Also discard all previous input in the minibuffer."
   (interactive)
-  (delete-minibuffer-contents)
-  (ding)
-  (discard-input)
-  (minibuffer-message "Wrong answer")
-  (sit-for 2))
+  (when (minibufferp)
+    (delete-minibuffer-contents)
+    (ding)
+    (discard-input)
+    (minibuffer-message "Wrong answer")
+    (sit-for 2)))
 
 (defvar empty-history)
 
@@ -2802,6 +2805,8 @@ read-char-from-minibuffer
                                  map read-char-from-minibuffer-map-hash)
                         map))
                 read-char-from-minibuffer-map))
+         ;; Protect this-command when called from pre-command-hook (bug#45029)
+         (this-command this-command)
          (result
           (read-from-minibuffer prompt nil map nil
                                 (or history 'empty-history)))
@@ -2856,28 +2861,31 @@ y-or-n-p-insert-y
   "Insert the answer \"y\" and exit the minibuffer of `y-or-n-p'.
 Discard all previous input before inserting and exiting the minibuffer."
   (interactive)
-  (delete-minibuffer-contents)
-  (insert "y")
-  (exit-minibuffer))
+  (when (minibufferp)
+    (delete-minibuffer-contents)
+    (insert "y")
+    (exit-minibuffer)))
 
 (defun y-or-n-p-insert-n ()
   "Insert the answer \"n\" and exit the minibuffer of `y-or-n-p'.
 Discard all previous input before inserting and exiting the minibuffer."
   (interactive)
-  (delete-minibuffer-contents)
-  (insert "n")
-  (exit-minibuffer))
+  (when (minibufferp)
+    (delete-minibuffer-contents)
+    (insert "n")
+    (exit-minibuffer)))
 
 (defun y-or-n-p-insert-other ()
   "Handle inserting of other answers in the minibuffer of `y-or-n-p'.
 Display an error on trying to insert a disallowed character.
 Also discard all previous input in the minibuffer."
   (interactive)
-  (delete-minibuffer-contents)
-  (ding)
-  (discard-input)
-  (minibuffer-message "Please answer y or n")
-  (sit-for 2))
+  (when (minibufferp)
+    (delete-minibuffer-contents)
+    (ding)
+    (discard-input)
+    (minibuffer-message "Please answer y or n")
+    (sit-for 2)))
 
 (defvar empty-history)
 
@@ -2955,6 +2963,8 @@ y-or-n-p
                              (let ((help-form msg)) ; lexically bound msg
                                (help-form-show)))))
                        map))
+             ;; Protect this-command when called from pre-command-hook (bug#45029)
+             (this-command this-command)
              (str (read-from-minibuffer
                    prompt nil keymap nil
                    (or y-or-n-p-history-variable 'empty-history))))